Ivory Coast will face off with Egypt in the 2021 Africa Cup of Nations (AFCON) Round of 16 match on January 26. 
 

Sevilla will be seeking their fourth successive La Liga win against Celta Vigo when they clash at the Ramon Sanchez Pizjuan on January 22.
 

Southampton will attempt to stop the juggernaut that is Manchester City when they do battle in a Premier League clash at St Mary's on January 22.

Inter Milan will battle it out with Venezia FC in an Italian Serie A match at the Stadio Giuseppe Meazza on January 22.

Getafe CF will square off with Granada CF in a Spanish La Liga match at the Coliseum Alfonso Pérez on January 20.

Manchester United will target a return to winning ways when they travel to Villa Park for a Premier League clash against Aston Villa on January 15.
 

Gabon will square off with Ghana in the 2021 Africa Cup of Nations (AFCON) Group C match on January 14.
 

AS Roma will go head to head with Cagliari in an Italian Serie A match at the Stadio Olimpico on January 16.
 

Morocco and Ghana will get their Group C Africa Cup of Nations campaign underway with a heavyweight battle at the Stade Ahmadou Ahidjo in Yaounde on the evening of Monday 10 January 2022, kick-off at 16:00.

Udinese will be desperate to end their barren spell against Atalanta when they square off in a Serie A clash at Stadio Friuli on January 9.